Endocrine Abstracts

The aim of the study: Acromegaly is associated with respiratory and cardiovascular morbidities and high mortality rate. The present study evaluates clinical aspects in acromegalic and obese patients with sleep apnea syndrome (SAS).Material and method: The patients were diagnosed and followed-up in the Clinic of Endocrinology, Timisoara, in the period 2006–2009. All the cases were confirmed and investigated as present guidelines recommend. The polyso...

Introduction: Isolated maternal hypothyroxinemia leads to higher prevalence of children autism, attention-deficit/hyperactivity disorder and mild cognitive deficiency. Frequency of hypothyroxinemia among women with gestational diabetes mellitus (GDM) is unclear and routine screening is not well established.Objective: Find prevalence of maternal isolated hypothyroxinemia in women with GDM and assess relations with necessity of insulinotherapy.<p class...

The aim of the present study was to evaluate and compare the response of 17 OHP to ACTH stimulation in patients with various types of adrenal incidentalomas and to examine the occurence of germline CYP21 mutation in these patients.Subjects and methods: Forty patients (27 females, 13 males) with unilateral and bilateral masses were screened for five most common mutations of the CYP21 in peripheral blood DNA samples. A hormonal evaluation, i.e. baseline pl...

Background: Pseudohypoparathyroidism (PHP) is a heterogeneous group of disorders characterized by hypocalcemia, hyperphosphatemia, increased serum concentration of parathyroid hormone (PTH) and insensitivity to the biological activity of PTH.Case report: We present the case of a 38-year-old man admitted to the Neurology Clinic in November 2007 for a witnessed grand mal seizure that resolved without intervention. Patient had a history of mental retardatio...

Introduction: Left hepatic lobe volume (LHLV) has been associated with hyperinsulinemia and insulin resistance in obese women.Aim: To study the correlation between LHLV and body weight, regardless the weight and gender of the patient.Subjects and methods: The left hepatic lobe was evaluated with an echographic probe of 3.5 MHz. The LHLV (cm3) was calculated with the formula: antero-posterior diameter (length)×longit...

The study evaluates the expression of same immunohistochemical (IHC) markers (Ki-67, PCNA, CK-19, HBME-1 and Galectin 3, in the diagnosis of differentiated thyroid carcinomas.Material and methods: The study group comprised 57 patients with thyroid tumors; aged 17–71 years (mean age 48.96 years). All cases were evaluated before surgical treatment by means of clinical examination, thyroid ultrasonography and fine needle aspiration biopsy (FNAB).<p...

It is well known that adrenal masses, particularly adenomas are frequently related to metabolic syndrome and insulin resistance. However, there are no reported data about the differences between adenomas and hyperplasia.Authors examined the prevalence of symptoms of the metabolic syndrome and insulin resistance in 25 patients with adrenal incidentalomas (10 men, 15 women) of the mean age 57.9+15 years. 15 patients had adrenal adenoma determined by CT or ...

Primary therapy in prolactinomas, the most frequent pituitary adenomas, consists in ergot derivatives dopamine agonists (bromocriptine or cabergoline) which lowers prolactin levels and shrink the tumour. Bromocriptine was the first drug used, but the therapeutic levels are attained after several days/weeks, therefore an acute suppression test is not possible. However, the biological response is variable and 10% of prolactinomas are resistant to medical therapy. In order to eva...

Introduction: We report a case of adrenal tumor recurrence after bilateral adenomectomy for Cushing’s syndrome.Case report: A 44-year-old female diagnosed in June 2014 with Cushing’s syndrome caused by bilateral adrenocortical tumors, which were identified by an abdominal CT (right tumor-2.6/ 2/1.8 cm, left tumor-3/2/2 cm). At presentation, the patient had typical signs and symptoms of hypercortisolism and complications such as: arterial hypert...

Alzheimer’s disease (AD) is a neurodegenerative disease that manifests itself in the gradual loss of cognitive and behavioral functions. In humans, glucagon is processed in pancreatic alpha cells located next to insulin-secreting beta cells, suggesting a local interaction. Glucagon is also produced in the intestinal L-cells and in small amounts in the hypothalamus. The main function of glucagon is to counteract the effects of insulin and thus maintain balanced blood gluco...